Editorial Perspectives: will SARS-CoV-2 reset public health requirements in the water industry? Integrating lessons of the past and emerging research
Edgar Wright’s Baby Driver is one of the most entertaining thrill rides of this year, this decade. This century.
Editorial Perspectives: 2019 novel coronavirus (SARS-CoV-2): what is its fate in urban water cycle and how can the water research community respond?
Coke's Kent is not the only chief executive who spoke out in 2013 about the merits of immigration reform for big business.
Nano and biosensors for detection of SARS-CoV-2: challenges and opportunities
Soft matter science and the COVID-19 pandemic
Carbon-based antiviral nanomaterials: graphene, C-dots, and fullerenes. A perspective
Carve out a place at home that is your study space. If you've got a family around you, make sure everyone understands that when you're in that space, you're not to be interrupted unless the house is on fire.
Ultraviolet-C and other methods of decontamination of filtering facepiece N-95 respirators during the COVID-19 pandemic
2014年，演员蒂尔达·斯文顿(Tilda Swinton)在四部电影中戴着假牙：《零点定理》(The Zero Theorem)、《布达佩斯大饭店》、《唯爱永生》(Only Lovers Left Alive)，以及奉俊昊导演的《雪国列车》(Snowpiercer)。在最后这部惊悚片中，斯文顿饰演残酷、狡猾的梅森部长(Minister Mason)，她戴着一副大大的眼镜，有一口庞大、丑陋的牙齿。
10. You've just been acting weird, OK?
1.Mitsubishi. Brand love: -12% / Rank: 360
Trends and targets in antiviral phototherapy
But the UK courts may land a heavy blow on ride-hailing app Uber. In 2017, the California-based company failed to persuade an appeal judge that two of its London drivers are independent contractors. In 2018, the test case will go to the Court of Appeal and possibly to the Supreme Court. If Uber loses the case and is told to assume the responsibilities of an employer, the implications will ripple far and wide.
Her predecessor David Cameron placed fifth in CNNMoney's previous ranking in March 2015 with his salary of ￡142,500, then worth $214,800. May is only seventh.
Two days ago here in Brazil, we were shocked when we spent some time with some children living on the streets. And this is what one child told us: "I wish I was rich and if I were, I would give all the street children food, clothes, medicine, shelter and love and affection." 在巴西，我被2天前见到的情景震惊了，那时我和当地的小孩在玩耍，其中一个小孩说：“我希望我能富裕起来，然后我会给这个街道所有的小孩饭吃，给他们衣服穿，医疗，住房和爱”。
A new point-of-care test for the diagnosis of infectious diseases based on multiplex lateral flow immunoassays
Novel biosensing methodologies for ultrasensitive detection of viruses
Anti-tumor, -viral, and -bacterial activities of polyoxometalates for realizing an inorganic drug
New employees at the company's Tulsa headquarters have little time to be shy: on their first days, they're seated at desks with a tub of candy. Colleagues often stop by and introduce themselves while grabbing a snack.
Will the Saudi Aramco public offering debut on an international market
ACE2 as a potential therapeutic target for pandemic COVID-19
Best chance: If there are nine or 10 best picture nominees, it could grab a spot. Jordan Peele's screenplay looks certain to be recognized.
Diagnostic technologies for COVID-19: a review
The Spring Festival Travel Rush, also known as Chunyun in Chinese, or Spring Festival Travel Season / Transportation Peak is considered to be the largest annual migration.It is the special period when China faces an extremely high traffic load, which results in great transportation problems, especially on the railway services.
Targeting severe acute respiratory syndrome-coronavirus (SARS-CoV-1) with structurally diverse inhibitors: a comprehensive review
Profit at property insurers fell 43.39 per cent year-on-year to Rmb33.7bn. For life insurance firms it dropped 65.6 per cent to Rmb54.2bn, while for reinsurers it fell 58.8 per cent to Rmb4.4bn.
An overview of key potential therapeutic strategies for combat in the COVID-19 battle
Statistics from another market research firm, Counterpoint, indicate that China shipped 465 million smartphones over the last year, accounting for nearly one-third of the global volume.
Potential repurposed SARS-CoV-2 (COVID-19) infection drugs
The survey of 11,500 workers by Chinese employment agency Zhaopin found that 50.9 per cent did not get an annual bonus at the end of 2016. Another 9.6 per cent were told their bonus had been delayed until after the new year holiday.
Nature as a treasure trove of potential anti-SARS-CoV drug leads: a structural/mechanistic rationale
In search for effective and definitive treatment of herpes simplex virus type 1 (HSV-1) infections
Antiviral drug discovery: broad-spectrum drugs from nature
In the past decade, only three blue diamonds of 10 carats or more with the same vivid grading for intensity have been sold at auction, all weighing less than 12 carats and none flawless, he said.
Meanwhile, in an unfortunate red carpet faux pas, Pink and Shakira both showed up in the same Balmain dress.
Influenza neuraminidase: A druggable target for natural products
除了P2P贷款领域发展迅速以外，今年还涌现出一些网络银行和贷款机构——比如腾讯(Tencent)的微众银行(WeBank)、阿里巴巴(Alibaba)的网商银行(Mybank)，以及蚂蚁金融(Ant Financial)的芝麻贷(Sesame Credit)。
Marco Montanari, the head of passive asset management for Asia-Pacific at Deutsche AM, agrees that fundamental changes to distribution must be made before the Asian ETF market can move to the next level.
Emerging investigators series: the source and fate of pandemic viruses in the urban water cycle
Investigators have arrested one youth and one 18-year-old in connection to the July 9th shooting.
The role of biosensors in the detection of emerging infectious diseases
Quantitative determination of mechanical stability in the novel coronavirus spike protein
Interaction of hydroxychloroquine with SARS-CoV2 functional proteins using all-atoms non-equilibrium alchemical simulations
Mr. Murray came to her with a full beard, so she was able to shape it into the thick, bushy mustache pictured here. “Bill has never worn that look before,” Ms. Hannon said, “so it was lovely to get something new.”
The Democratic party's would-be challenger, Republican frontrunner Donald Trump, responded on Fox News, accusing Clinton of pandering to female voters.
Sonneborn says he's been dismayed not only by what he sees as Trump's troubling decisions and juvenile moments but also by the president's response after a counterprotester was killed during the August white nationalist rally in Charlottesville, Virginia — which is what cemented Sonneborn's decision to seek office.
MPLEx: a method for simultaneous pathogen inactivation and extraction of samples for multi-omics profiling
Episodic memory is also known as long-term memory, and the researchers approached the study of exercise in a different manner than previous studies. Other studies examined the impact of aerobic exercise conducted over many months, but this study simply asked participants to lift weights a single time. During the test, half of the participants were asked to use a weight machine before recalling a series of images they were shown at the start of the test. The other half of the participants were also asked to recall the images but without having engaged in any strenuous activity before the recall session. In demonstrating the memory improvement for the participants who engaged in just a single session of weight lifting, the researchers were able to show that improving one's memory through exercise didn't take hours of dedication in the gym. The next time you have the opportunity to lift weights or someone tries to convince you to join the gym you might just want to take him or her up on the offer.
No one since Michael Haneke has enjoyed cinematically dissecting social conventions as much as Greek film-maker Yorgos Lanthimos. His The Lobster took Cannes by storm two years ago with its scathing look at a society that turns adults into animals if they cannot find a romantic partner within 45 days – it was our world but pushed toward the outermost limits of groupthink and conformity. Now he’s back with The Killing of a Sacred Deer, a domestic thriller about a surgeon (Colin Farrell) and his wife (Nicole Kidman), also a doctor, who befriends a fatherless teen named Martin. The boy seems determined to expose the family’s secrets and unmask a terrible trauma from their past. Is this film about how domestic (and perhaps societal) tranquility sometimes depends on shared, agreed-upon lies? Either way, prepare to be unnerved. Released November 9 in Denmark, November 16 in Russia and November 30 in China's Hong Kong. (Credit: A24)
Multicolored silver nanoparticles for multiplexed disease diagnostics: distinguishing dengue, yellow fever, and Ebola viruses
Inhibition of SARS coronavirus helicase by bismuth complexes
《弗鲁特维尔车站》(Fruitvale Station)是另一部出色的故事片处女作，由瑞安?库格勒(Ryan Coogler)执导。这部影片的主题是赤手空拳的22岁黑人奥斯卡?格兰特(Oscar Grant)在加州奥克兰与一名白人交警发生冲突而遭到误杀，这本来可以成就一部纪录片。库格勒有更好的想法，将这个真实事件加以戏剧化改编，并在很大程度上进行了虚构，讲述了奥斯卡死亡前一天的生活。饰演这个角色的是迈克尔?乔丹(Michael Jordan)，他的表演能让你心碎，也能令人欢乐不已，有时是两者兼具。
根据中国海关总署(General Administration of Customs)发布的数据，12月份以美元计的出口额同比减少6.1%至2094.2亿美元。这一跌幅比经济学家预期的中数多了2.1个百分点，也大于11月份修正后1.6%的跌幅（修正前该数字为增长0.1%）。
Against: Opening so early in the year outside of awards season could hinder its chances.
Unveiling the molecular mechanism of SARS-CoV-2 main protease inhibition from 137 crystal structures using algebraic topology and deep learning
A serological aptamer-assisted proximity ligation assay for COVID-19 diagnosis and seeking neutralizing aptamers
Revealing the molecular mechanisms of proteolysis of SARS-CoV-2 Mpro by QM/MM computational methods
The molecular mechanism of the proteolysis reaction catalyzed by SARS-CoV-2 Mpro, one of the enzymes essential for the replication process of the virus responsible for the COVID-19 pandemic, is described using computational QM/MM methods.
Multi-targeting of functional cysteines in multiple conserved SARS-CoV-2 domains by clinically safe Zn-ejectors
By combining evolutionary and physico-chemical principles, previously unknown druggable Zn-sites in multiple conserved SARS-CoV-2 domains have been identified.
Computer-generated “synthetic contingency” plans at times of logistics and supply problems: scenarios for hydroxychloroquine and remdesivir
The blocks of flats which were up to 12 storeys high in the city of Wuhan are making way for a huge new business district including a 707-metre tall skyscraper.
Engineered unnatural ubiquitin for optimal detection of deubiquitinating enzymes
周边环境：斯托宁顿位于康涅狄格州东南部的小纳拉甘西特湾(Little Narragansett Bay)，从哈特福特(Hartford)和罗德岛的普罗维登斯(Providence, R.I.)开车约1小时可达，从纽约市开车约3小时。这里曾是一个具有悠久历史的繁忙港口，至今仍然保留着一支商业捕鱼船队，有几个分布着殖民式和联邦式建筑的历史区，以及一个繁荣的航海社区。在该镇的一端有个小型的公共海滩，而在另一端罗德岛的沃奇·希尔(Watch Hill)则有个大得多的海滩，开车大约20分钟可到。这栋希腊复兴式房屋带有此类建筑必不可少的爱奥尼亚柱和山形墙上的扇骨半圆窗，房屋就坐落在市镇中心。
A Digital Protein Microarray for COVID-19 Cytokine Storm Monitoring
Accelerating the repurposing of FDA-approved drugs against coronavirus disease-19 (COVID-19)
A point-of-care selenium nanoparticle-based test for the combined detection of anti-SARS-CoV-2 IgM and IgG in human serum and blood
After rising every year since 2008 global gold supply plateaued last year, according to the World Gold Council. In China, the world’s biggest producer, it fell by a record 9 per cent, the second time output has fallen in the country since 1980.
Assessing potential inhibitors of SARS-CoV-2 main protease from available drugs using free energy perturbation simulations
The inactivation mechanism of chemical disinfection against SARS-CoV-2: from MD and DFT perspectives
Why was I so confident that there would be no war in east Asia, either in the East China Sea or the South China Sea? The simple answer is that I know the Asian dynamic. While many Asian neighbours will make angry nationalist statements (and they have to do so to manage popular nationalist sentiments), they are also careful and pragmatic in their deeds.
Antiviral agents against COVID-19: structure-based design of specific peptidomimetic inhibitors of SARS-CoV-2 main protease
Pharmacophore-based approaches in the rational repurposing technique for FDA approved drugs targeting SARS-CoV-2 Mpro
A study cited in an article from Harvard University suggests your diet could have a significant impact on your memory as you age. Scientists at Brigham and Women's Hospital published a study within the "Annals of Neurology" that suggested women who ate high levels of saturated fat in foods like red meat and butter didn't perform as well on memory tests than women who regularly consumed less saturated fat. Researchers haven't yet discovered the connection between saturated fat and memory, but they hypothesize it could have something to do with a person's genes. Scientists and doctors have long recommended that patients work to control their cholesterol levels as they age to protect the memory during the aging process.
Amino acid interacting network in the receptor-binding domain of SARS-CoV-2 spike protein
Greener liquid-phase synthesis and the ACE inhibitory structure–activity relationship of an anti-SARS octapeptide
4.British people may seem to apologise a lot, but it doesn't quite mean the same thing here. In the UK, "I'm sorry" actually means either a) I didn't hear you; b) I didn't understand you; or c) I both heard and understood you, and I think you're an idiot.
Unfortunately for May, the big drop in the pound since the Brexit vote means her salary has plunged in dollar terms.
If you have a question, come to my office. Don't corner me in the bathroom.
Anti-inflammatory, antiallergic and COVID-19 protease inhibitory activities of phytochemicals from the Jordanian hawksbeard: identification, structure–activity relationships, molecular modeling and impact on its folk medicinal uses
“Climate change is perhaps the major challenge of our generation,” said Michael H. Freilich, director of earth sciences at NASA, one of the agencies that track global temperatures.
The biomaterial polyphosphate blocks stoichiometric binding of the SARS-CoV-2 S-protein to the cellular ACE2 receptor
Among the top 50 richest women in the world, entrepreneurs from the Chinese mainland account for 56%.
Ilimaquinone (marine sponge metabolite) as a novel inhibitor of SARS-CoV-2 key target proteins in comparison with suggested COVID-19 drugs: designing, docking and molecular dynamics simulation study
The Aftermath of Zika Virus
"This is something we believe is really important for the future of our country,"Facebook (FB, Fortune 500) CEO Mark Zuckerberg said in August.
Design and optimization of a subunit vaccine targeting COVID-19 molecular shreds using an immunoinformatics framework
Song “Wind Blowing In The Wheat Field” (Li Jian and Sun Li)
Several coumarin derivatives and their Pd(II) complexes as potential inhibitors of the main protease of SARS-CoV-2, an in silico approach
Coumarin derivatives and their Pd(II)-complexes have shown a higher binding potential towards SARS-CoV-2 Mpro than chloroquine/cinanserin along with lower toxicity.
Carotane sesquiterpenes from Ferula vesceritensis: in silico analysis as SARS-CoV-2 binding inhibitors
Sesquiterpenes, 8α-anisate-dauc-4-ene-3,9-dione (webiol anisate) (1) and 10α-acetoxy-6α-benzoate-jaeschkeanadiol (2) as well as several analogues (3–12) were root extracted from Ferula vesceritensis.
Quinazoline-Schiff base conjugates: in silico study and ADMET predictions as multi-target inhibitors of coronavirus (SARS-CoV-2) proteins
Design of 2-phenylquinazolin-4(3H)one-trihydroxyphenyl Schiff base conjugates as COVID-19 therapy.
Automated multiplex nucleic acid tests for rapid detection of SARS-CoV-2, influenza A and B infection with direct reverse-transcription quantitative PCR (dirRT-qPCR) assay in a centrifugal microfluidic platform
In news that should come as little surprise to global air travelers, Singapore's done it again.
《失常》，导演查理·考夫曼(Charlie Kaufman)与杜克·约翰逊(Duke Johnson)。
A modular microarray imaging system for highly specific COVID-19 antibody testing
Wearing a black leotard and curled hairpiece, beauty queen Bobbi Boyden shakes her hips and blows kisses to the audience as part of her routine.
Development of a tablet PC-based portable device for colorimetric determination of assays including COVID-19 and other pathogenic microorganisms
When you need help, reach out to people in your networks – that’s what they’re there for. Whether you need a confidence-boosting pep talk or advice about building your technical experience — your mentor, your colleagues, and your manager can help. You may not know how to do something today, but chances are you’re smart enough to find someone who can help you learn it. And once you do, don’t unfasten your seatbelt – there’s always going to be another challenge headed your way.
Inhibition of SARS-CoV-2 main protease by phenolic compounds from Manilkara hexandra (Roxb.) Dubard assisted by metabolite profiling and in silico virtual screening
1.Photography: 22.3 percent increase
Rapid prediction of possible inhibitors for SARS-CoV-2 main protease using docking and FPL simulations
A combination of Autodock Vina and FPL calculations suggested that periandrin V, penimocycline, cis-p-Coumaroylcorosolic acid, glycyrrhizin, and uralsaponin B are able to bind well to SARS-CoV-2 Mpro.
Curcumin to inhibit binding of spike glycoprotein to ACE2 receptors: computational modelling, simulations, and ADMET studies to explore curcuminoids against novel SARS-CoV-2 targets
"Sydney's housing prices shot up because foreign investors are buying trophy assets, in places like Bondi," says Elliot.
A density functional theory study on silver and bis-silver complexes with lighter tetrylene: are silver and bis-silver carbenes candidates for SARS-CoV-2 inhibition? Insight from molecular docking simulation
Good luck and great success in the coming New Year.
An in silico perception for newly isolated flavonoids from peach fruit as privileged avenue for a countermeasure outbreak of COVID-19
3′-Hydroxy-4′-methoxy-chroman-7-O-β-D-glucopyranoside 4, together with three known compounds, ferulic acid heptyl ester 1, naringenin 2, and 4,2′,4′-trihydroxy-6′-methoxychalcone-4′-O-β-D-glucopyranoside 3, was isolated from peach fruits.
Understanding the role of galectin inhibitors as potential candidates for SARS-CoV-2 spike protein: in silico studies
The improvements in education levels mirrored the development of China's education system. Independent research into China's education situation showed that overall education development was better than the world average last year, Yuan Guiren, minister of education, said in March.
Characterization of a commercially-available, low-pressure UV lamp as a disinfection system for decontamination of common nosocomial pathogens on N95 filtering facepiece respirator (FFR) material
Are you looking at the clothes? Eva Longoria Parker stripped off as she posed with husband Tony to advertise the London Fog fashion line. Eva Longoria Parker s
A facile assay for rapid detection of COVID-19 antibodies
Potential role of medicinal plants and their constituents in the mitigation of SARS-CoV-2: identifying related therapeutic targets using network pharmacology and molecular docking analyses
You can read the full list of stories, but here are the top five:
Experts say that 2016 was a remarkable year for the Chinese film industry as it realized growth while facing multiple challenges including the rapid development of the internet, the increasingly sophisticated tastes of Chinese audiences, and the economic downturn in the country.
Remdesivir-bound and ligand-free simulations reveal the probable mechanism of inhibiting the RNA dependent RNA polymerase of severe acute respiratory syndrome coronavirus 2
Type D personalities usually have a low self-esteem and a great fear of disapproval and this is the primary reason that prevents them from opening up to others.
Consensus virtual screening of dark chemical matter and food chemicals uncover potential inhibitors of SARS-CoV-2 main protease
Here are five things consumers and investors can count on (probably) in 2015:
That's particularly striking in Brazil, with its highly mixed population that has more blacks than any country with the exception of Nigeria. More than half of Brazil's population self-identified themselves as black or of mixed-race in the 2010 census.
Clinical decision support tool and rapid point-of-care platform for determining disease severity in patients with COVID-19
Whole-genome sequence analysis and homology modelling of the main protease and non-structural protein 3 of SARS-CoV-2 reveal an aza-peptide and a lead inhibitor with possible antiviral properties
Molecular docking reveals the potential of Salvadora persica flavonoids to inhibit COVID-19 virus main protease
Molecular docking reveals the potential of Salvadora persica flavonoids to inhibit COVID-19 virus main protease.
Smartphone-based multiplex 30-minute nucleic acid test of live virus from nasal swab extract
2013 Rank: 3
Anti-HIV drug repurposing against SARS-CoV-2
Friends wasn't known for being the most diverse show on television at the time, since the cast was comprised of almost entirely white actors. None of the main characters were anything other than "mainstream." Even the acknowledgement of Ross's first wife Carol being a lesbian was met with jokes about sexuality (mostly from Joey), and sexist comments were frequently incorporated into the script.
Length-scale dependence of protein hydration-shell density
3. Enlisted military personnel
Chris Washington, played by London-born Daniel Kaluuya, is drawn into the sinister underbelly of a small American community.
The year before, Taiwanese anti-China protesters chose the sunflower as the symbol for their cause.
High antiviral activity of mercaptoethane sulfonate functionalized Te/BSA nanostars against arterivirus and coronavirus
Subdivided flats smaller than 100 square feet (9 square meters) can rent for $385 in the Asian city.
A handheld continuous-flow real-time fluorescence qPCR system with a PVC microreactor
About this collection
《战地神探》(Foyle’s War)，acorn.tv，2月2日播出。去年流媒体服务网络Acorn TV放完了《大侦探波洛》(Agatha Christie’s Poirot)的最后三集，如今又带来另一部传统英国推理剧，这部超级剧集在英国已经拍到第九季，在美国还是首次播出。迈克尔·基臣(Michael Kitchen)在剧中饰演克里斯托弗·弗伊(Christopher Foyle)，一位可敬而又狡黠的侦探，这部剧多年来从一部“二战”后方警探剧演变成勒卡雷(le Carré)式的冷战惊悚剧。新的几集中有纽伦堡审判以及英国在巴勒斯坦所扮演的角色。